What is detoxification? Definition: de•tox•i•fi•ca•tion (dē-tŏk′sə-fĭ-kā′shən) n. 1. The process of detoxifying. 2. The state or condition of being detoxified. 3. Physiology – The metabolic process by which the toxic qualities of a poison or toxin are reduced by the body. There are many people that want to bash the idea of detoxing and the...